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We synthesized a novel multi-fluorescence sensor which can respond to both pH and temperature. This kind of sensor was based on amino-polystyrene microbeads and two different fluorescent indicators (Rhodamine B and FITC) were applied simultaneously to synthesize the multi-sensor. Rhodamine B shows an excellent linear relationship between the relative fluorescent intensity and temperature while it...
Microsphere-based therapy is used to allow drug release to treat the critical site through the choice and formulation of variations drug-polymer combinations. They are also used to control the release of insoluble drug by the biodegradability of polymer. Chitosan is one of the candidates for the polymer matrix because their biodegradability and biocompatibility. Recently, we prepared and characterized...
We proposed the new method to assemble 3D cell structures using hysteresis character of thermoresponsive polyer solution. In this paper, we conducted cell culture inside thermoresponsive polymer solution to check whether cells can grow inside the gel. A ultra-low attachment flask was used to culture cells for preventing cell attachment on the surface and check the effect when cells were embedded inside...
PIPAAm grafted polystyrene (PIPAAm-Pst) dishes were prepared using visible light irradiation and polystyrene dishes modified with thioxanethone-based photoinitiator. At optimized preparation conditions, PIPAAm-PSs fabricating cell sheets were successfully prepared by 5 mins visible light irradiation. After PIPAAm polymerization, micro-patterned temperature responsive polystyrene culture surface (MPTRCS)...
We have synthesized novel Mussel-mimetic glues (adhesive polymer) from plant-derived monomers. Because the adhesive polymer contains catechol group at their chain ends, which is similar chemical structure of 3,4- dihydroxyphenyl-L-alanine (dopa) produced by Mussel, it demonstrated strong adhesive characteristics onto organic and/or inorganic surfaces beyond instant super glue. The origin of this strong...
Many types of functional gels have been developed and applied to soft actuators or artificial muscles. In particular, electroactive polymer gels that change shape when controlled electrically seem to be promising. But the mechanical motion is driven by electric stimuli. In the present study, we describe the autonomous hydrogel locomotion powered by the chemical energy. The polymer gels can generate...
Biohybrid systems, formed by combining biological cells and artificial components has a potential to resolve the current technical limits of traditional microactuators. We demonstrate fabrication of microstructures, which can be coupled to Vorticella convallaria. Structures were fabricated by microfluidic in situ photolithography techniques, and movable components were developed. We evaluated viability...
This paper presents an environment friendly fabrication technology of MEMS devices using biodegradable polymer material applying hot embossing and polishing process. The capability of the method was demonstrated through the fabrication and tested of a polylactic acid (PLA) thermal microactuator. The displacement was about 11 times larger than that of a Si counterpart. In this research, a monolithic...
We have developed a three-dimensional (3-D) molding process for the production of piezoelectric ceramic elements by using a master polymer mold produced by microstereolithography. In this method, ceramic slurry is injected into a 3-D polymeric mold via a centrifugal casting process. The polymeric master mold is thermally decomposed so that complex 3-D piezoelectric ceramic elements can be produced...
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