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This paper reports a novel on-chip cellular force measurement method of single cells using Direct-Outer-Drive mechanism (D-O-D mechanism). This D-O-D mechanism enables high speed (1 kHz), high power (1 kN) and high accurate manipulation (nanometer-order) of Robochip (Robot-integrated microfluidic chip) and mechanical property measurement of single cells. We succeeded in mechanical property measurement...
Biomechanical properties of cells have been identified as an important factor in various biological processes. As cells migrate collectively, they interact mechanically with their surrounding cells. Thus, it is crucial to quantify mechanical properties of cell population in a large scale from intra-to inter-cellular regions. To measure the stiffness of confluent cells in a large scale, we developed...
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