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This paper reports fabrication of retinal microvessels model for evaluation of microcannulation. Because microcannulation as a new treatment for retinal vein occlusion is difficult surgery operation, development and evaluation of microsurgical robot systems to assistant vitreoretinal surgery is needed. Evaluation of microcannulation needs a retinal microvessels model without individual difference...
In order to elucidate the effects of nanomechanical stimulation on the regulation of cellular functions, we have been developing a cell culture microdevice integrated with piezoelectric thin film actuators. In this paper, we propose a new geometric configuration of the device to allow cell culture on a relatively flat surface and in an open space. An improved fabrication process for PZT actuators...
We developed a highly functional untethered micro-robot that can manipulate cells with high gripping force in a micro-fluidic chip. The robot has gripping mechanism which is actuated by magnetic power. A permanent magnet is attached at the center of the gripping mechanism, and an electrical magnet controls the position of the magnet from the bottom of the micro-fluidic chip. The open-close accuracy...
We present the fabrication of micro-sorting device with multiple-size pores micro-channel. The porous micro-channel has 1, 3, and 5 μm diameter. It was fabricated by direct laser writing. It was designed to connect with micro-channels which were fabricated by UV lithography process. The multiple-size pores micro-channel was made of IP-L as photoresist. The PDMS micro-channel has also been fabricated...
Biohybrid systems, formed by combining biological cells and artificial components has a potential to resolve the current technical limits of traditional microactuators. We demonstrate fabrication of microstructures, which can be coupled to Vorticella convallaria. Structures were fabricated by microfluidic in situ photolithography techniques, and movable components were developed. We evaluated viability...
Assembling engineered tissues at the mesoscale into an engineered organ has specially attracted our attention since engineered organ usually has a very complex structure and cannot be fabricated simply by using a fixed scaffold. The fabrication of these composite tissues is, however, difficult since many different scaffolds are required. The flexible microsaffold, called “changeable cell culture (C...
Microfluidic devices provide efficient approaches for building bio-mimetic tubular structures for in vitro tissue models. In this paper, we report a novel method of constructing multilayered tubular structures embedding cells via a 2-layer microfluidic device. The on-chip fabrication of movable microstructures embedding fibroblasts (NIH/3T3) based on Poly (ethylene glycol) Diacrylate (PEGDA) was reported...
A novel rail-guided dextrous stick coordination manipulation (DeSCom) system was proposed for the assembly of cell-laden three-dimensional (3D) constructs. The coordination control between three dextrous sticks was realized based on the vision feedback and the manipulation resolution was around 30 nm. It was set up with hybrid motors to ensure the large operation range and operation precision. The...
Magnetic hydrogel microbeads have wide applications in the fields of biological engineering and regenerative medicine. In the paper, we proposed a new method for fabricating the magnetic hydrogel beads by encapsulating the magnetic resonance imaging (MRI) contrast media inside the polyethylene glycol diacrylate (PEGDA) solution. Then a microfluidic device was prepared for crosslinking the magnetic...
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