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Micro- and nanoscale structures on a material surface formed by femotosecond laser processing have greatly changed its optical characteristics. In this work, the coloring of Al surface has been realized with scanning focused femtosecond laser beam on the Al surface. We further apply femtosecond laser filamentation to form micro- and nano-structures on a spherical Al surface, resulting in a black appearance...
Periodic and quasi-periodic structures on silicon surface have numerous significant applications in photoelectronics and surface engineering. A number of technologies have been developed to fabricate these structures in various research areas. In this work, we take the strategy of direct nanosecond laser interference patterning technology. Well-defined grating and dot structures have been achieved...
This paper describes a method of determining two-dimensional phase shifts. In this method, the two-dimensional phase shift is divided into horizontal and vertical components, and each component of the phase shift is determined by pattern correlation, Pythagorean theorem and linear interpolation with subpixel accuracy. The computer simulation and experiment have shown that the method is useful for...
AFM (atomic force microscope) imaging in liquids is very important in measurement science for bio-applications. This paper discusses the effect of liquids on AFM imaging. In a developed AFM system, a standard 2D grating was used for the study of AFM imaging in different liquids including deionzed water, DMEM (Dulbecco's Modified Eagle Medium) and DMEM with 10% of FBS (Fetal Bovine Serum). AFM images...
A method is presented to monitor and analyze tumor cells' biological process by image processing techniques based on an optical microscope in this paper. Meanwhile, the hybrid operation combination of the micro and nano manipulation plays a crucial role in studying living cells' biological process and the interactions of cells and drugs. In this paper, we propose an improved image segmentation method...
In this paper, we describe a novel nano manipulator based on an atomic force microscope (AFM). The body of the manipulator is enough compact to be operated inside the sample chamber of a scanning electron microscope (SEM). In order to realize the compact body, we employed a self-detection type cantilever for AFM observation. The cantilever includes strain resistance element, which can easily detect...
The use of large nanopatterned surfaces areas arouses a growing interest for the fabrication of templates, thin membranes, biomedical sensors and large-area photonic devices. Langmuir-Blodgett (LB) technique offers the possibility to deposit self-assembled monolayers of molecules and nanometric particles on surfaces exhibiting a structural order and uniformity at large scale. In this work, we studied...
This paper proposes a hybrid microassembly technique for massively parallel assembly of 200μm × 200μm × 30μm SU-8 chips. The hybrid microassembly technique combines the robotic pick-and-place technique and water mist induced self-assembly technique. The robotic handling tool is used to place microchips roughly on chips of the same size at a fast speed, and then water mist composed of microscopic droplets...
Manual operation of steerable catheter is inaccurate in minimally invasive surgery and requires dexterity for efficient manipulation of the catheter meanwhile exposes the surgeons to intense radiation. In this paper, our objective is to develop a remote control system that replaces the manipulation of surgeons with high accuracy. Increasing demands for flexibility and fast reactions in control method,...
The invention of atomic force microscopy (AFM) provides new technology for investigating the physiological activities at the single cell and single molecule levels. Lymphoma Raji cells were adsorbed onto the glass slides by coating the glass slides with poly-L-lysine. Rituximabs (anti-CD20 antibody) were linked onto the AFM tip by PEG linker and the CD20-Rituximab binding forces were measured on three...
In this paper a magnetophoretic chamber design is presented as a tool to evaluate the deflection patterns of magnetic microcarriers compatible with Magnetic Resonance Navigation (MRN) for drug delivery applications. Such micro-entities with different magnetic characteristics and subject to the force of a fluid flow show different deflection patterns while the effects of aggregations under different...
We present a continuous enucleation process of bovine oocytes on a microfluidic chip to achieve the continuous cutting of the oocytes and increasing the potential viability of the enucleated oocyte. By combining microfluidic chip and micororobotics, the flow in a channel can be actively controlled and we achieved successive operations of 1) loading oocyte, 2) control cutting volume and 3) removing...
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