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Automating chromosome classification and segmentation has been a major challenge in automated karyotyping especially due to overlapping chromosomes. The earlier reported methods for disentangling the chromosome overlaps have limited success as they are sensitive to scale variations, computationally complex, use only color information in case of multispectral imaging and most of them are limited to...
In this paper, we present a novel pulseoximetric sensor which can be worn in the ear channel. In previous work, we could demonstrate that measurement of heart rate (HR), arterial oxygen saturation (SpO2) and respiratory related information can be performed with reliable accuracy. Since these results were obtained under laboratory conditions, we now studied the feasibility of a clinical appliance of...
Clinicians generally agree that the most effective way to treat a malignant tumor within body organs is to detect it early. Currently, detection is mostly based on clinical diagnostics triggered by specific symptoms, which is often too late allowing the malignancy to reach an advanced stage. Automated high-resolution monitoring of body parts at regular intervals can be highly effective for detection...
Development of micro-fabrication technology, along with an ever increasing demand for reliable, low cost clinical health care has led to the realization of various BioMEMS devices. Present study aims for developing a flexible flow sensor on polymer substrate to monitor real-time blood flow and determine plague formation satisfying sensitivity, biocompatibility, and reliability requirements. Transient...
Physical inactivity is a leading risk factor in worldwide deaths. This problem has led to the need for new research paradigms investigating the effect of sedentary behavior on negative health outcomes. Central to this need is the development of objective and ubiquitous sensors that provide accurate measurements of activity to assist in intervention. Phone-based kinematic sensors, such as accelerometers...
Chronic obstructive pulmonary disease (COPD), a disabling combination of emphysema and chronic bronchitis, relies on spirometric lung function measurements for clinical diagnosis and treatment. Because spirometers are unavailable in most of the developing world, this project developed a low cost point of care spirometer prototype for the mobile phone called the “TeleSpiro.” The key contributions of...
Customization of stimulation parameters for individual patients is gaining considerable clinical importance in the context of increasing emphasis on personalized neuromuscular electrical stimulation (NMES) therapy. In the current study, the relationship between stimulation current intensities, muscle parameters and pulse width was ascertained using the method of theoretical modeling and testing in...
Obstructive sleep apnea (OSA) is a common sleep disorder found in 24% of adult men and 9% of adult women. Although continuous positive airway pressure (CPAP) has emerged as a standard therapy for OSA, a majority of patients are not tolerant to this treatment due to the uncomfortable nasal air delivery during their sleep. We introduce a Dirichlet process Gaussian Mixture (DPGM) model to predict the...
This paper proposes a HTML5 powered web ECG management system for telecardiology applications. A typical tele-ECG use case where General practitioner (GPs)/technicians wanting to consult their patient's ECG with a cardiologist, is realized using the proposed web application. It enables the GPs/technicians to share XML ECG of their patients with cardiologist in remote location and obtain his/her interpretations...
Although various electrical and non-electrical biosignal-monitoring miniaturized equipment have been developed, tested and employed, out of the traditional Hospital environment, it is only during the last few years that a comparable trend is appearing, concerning Laboratory and Respiratory Medicine. It is the purpose of this paper to present the development status of a system, supporting decision-making...
One of the main challenges in implementing an optimal home-based exercise program in older adults and individuals with cardiovascular conditions is the requirement to ensure exercise safety and prevention of any undesirable side effects. A crucial component to achieve this requirement is the ability to monitor blood pressure (BP) during exercise. The goal of this project was to introduce and to test...
Buruli ulcer (BU) disease is a devastating flesh-eating bacterial infection that each year affects thousands of people, but if detected early, it can be easily treated and cured. During the past several years, we have been developing an automated dermoscopy system for accurate analysis of skin lesions. In this paper, we describe our experience with BU detection in West Africa, and we focus on the...
The dilemma of cardiovascular disease in India is staggering, accounting for over 3 million annual deaths. A majority of India's population is rural and lacks adequate medical facilities for maintenance of cardiac health. Three main barriers of rural healthcare penetration in India include socioeconomic challenges, shortage of medical expertise, and underdeveloped infrastructure. In this paper we...
We developed a mobile ward round system based on openEHR for the use on smartphones and tablet computers using the Android platform which integrates and uses NFC to explore new ways of computer interaction, data processing and workflows in the medical world. Based on the automatic patient identification via NFC using the mobile device, physicians can easily view recent ward round results and edit/add...
The recording of auditory brainstem response (ABR) signals is a common measure applied to assess hearing impairments. However, most of the available commercial devices able to record ABR signals can be unaffordable for many medical centers because of their cost and low flexibility. This paper describes a system that allows the recording of high quality ABR. Its low cost, easy handling, high performance,...
When developing novel technologies for point-of-care medical devices it is important to keep in mind that use errors are a significant source of harm to patients. Some have estimated that a third of medical device incident reports to the US Food and Drug Administration involved use error. In order to make these novel point-of-care devices effective in developing countries, engineers must carefully...
Telemedicine interventions are being increasingly used in the care of adults with hypertension however application of these technologies in children with high BP has not been systematically studied. The goal of this project was to develop a mobile BP telemanagement system for children with hypertension and to evaluate its feasibility. The prototype system consisted of a home unit, decision support...
In this paper we describe an extendable point of care system for simultaneous motor rehabilitation (post-stroke and -arthroscopy) patient condition assessment and patient safety observations. Electronic linear and angular accelerometer sensors attached to the human upper or lower limbs gather information about performed therapeutic exercises. The measurement data processing of the vital sign sensors...
This paper reports a novel use of CMOS sensor technology in the development of microscopes, spectrophotometers and biosensors. A webcam CMOS Sensor was exploited to gain sufficient magnifications of carbon fibers (diameter 7 micrometers) and permanent slides of rat brain sections excluding use of any lens system for the purpose. Magnifications around 150 to 200 times were achieved using given CMOS...
Plantar sensory neuropathy (PSN) affects a large proportion of individuals suffering from type 2 diabetes. In order to avoid ulceration or other damage to patients' feet regular testing and assessment of PSN needs to be undertaken. Currently, the standard test involves a trained podiatrist visiting the patient and testing their feet manually with a simple hand-held nylon monofilament probe. This process...
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