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The aim of this work was to build up a new monitoring technique for the lung preservation. The medical aside problem is to measure the integrity and functionality of the lung tissue, specifically at cellular preservation level in order to improve the survival time until it is grafted. The Impedance monitoring technique for diagnosis edema development is the key in this new technique. The hypothesis...
The aim of the paper is to identify the key physiological variables and ventilator settings involved in ventilation management, and required for an appropriate Clinical Decision Support System (CDSS). Based on the results of a questionnaire designed for the purpose of the research, 70 hours of physiological and ventilation data were recorded. Recorded data were classified by clinicians into three...
Bivalirudin is direct thrombin inhibitor used in patients with heparin-induced thrombocytopenia. A pharmacokinetic and — dynamic model that predicts the partial thromboplastin time (PTT) based on the past infusion rates of bivalirudin following dose adjustment would be useful to guide optimal therapy. In this retrospective study we randomized 132 patients to a derivation and a validation cohort, and...
Continuous glucose monitoring systems are an integral component of diabetes management. Efforts to improve the accuracy and robustness of these systems are at the forefront of diabetes research. Towards this goal, a multi-sensor approach was evaluated in hospitalized patients. In this paper, we report on a multi-sensor fusion algorithm to combine glucose sensor measurements in a retrospective fashion...
A pressure sensor array placed below a mattress can be used to estimate the breathing effort signal unobtrusively. When multiple breathing effort sensor outputs are available, there is sometimes a need to choose the sensor with the best approximation of the actual breathing effort. Previous work with pressure sensor arrays placed on top of or under mattresses used for respiration rate and breathing...
Gait impairment is associated with increased falls risk. The gait of 321 community dwelling elderly adults was assessed using the TRIL Gait Analysis Platform (GAP), which was specially designed for ease of use in a research clinic setting by non-experts. The GAP featured body-worn kinematic sensors, a pressure sensitive electronic walkway, and two orthogonally mounted web cameras, and was developed...
The frequency of adverse cardiovascular events is greater in the morning compared to its 24-hour average. A circadian variation in the regulation of the cardiovascular system could contribute to this increased cardiovascular risk in the morning. Indeed, circadian rhythms have been shown for a wide array of physiological processes. Using an ultradian sleep-wake cycle (USW) procedure, we sought to determine...
The purpose of this study is to assess the Sleep Quality (SQ) in powernapping. The contributed factors for SQ assessment are time of Sleep Onset (SO), Sleep Length (SL), Sleep Depth (SD), and detection of sleep events (K-complex (KC) and Sleep Spindle (SS)). Data from daytime nap for 10 subjects, 2 days each, including EEG and ECG were recorded. The SD and sleep events were analyzed by applying spectral...
This paper presents a first version of a taxonomy of automatic sleep patterns found with the Affectiva Q™ Sensor, a wireless, logging biosensor that measures skin conductance, skin temperature, and motion comfortably from the wrist. Several studies have examined electrodermal activity (EDA) during sleep, but they focused on an analysis of EDA for only a small number of nights. We quantitatively analyzed...
Event-related potentials (ERPs) of a visual processing task are compared with and without a simultaneous external working memory load. Ten adults participated the same measurement session on three separate days. Results for visual ERP P3 amplitude and reaction time (RT) are presented for both task conditions. Both the reaction time of the visual task and the respective P3 latency increased during...
The excitation specificity of QT dynamic parameters was tested on three groups of subjects: healthy subjects; non-medicated hypertensive subjects with metabolic syndrome; and subjects with essential hypertension. Four different excitations of RR were used: bicycling exercise; tilt with breathing 0.1 and 0.33 Hz; and deep breathing. Linear dynamic feedback model of QT/RR coupling was supposed at the...
Tikhonov regularization is one of the most widely used regularization approaches in literature to overcome the ill-posedness of the inverse electrocardiography problem. However, the resulting solutions are biased towards the constraint used for regularization. One alternative to obtain improved results is to employ multiple constraints in the cost function. This approach has been shown to produce...
We evaluated neurovascular and autonomic response to a Divided Attention task within a group of 16 healthy subjects, by means of Electroencephalography, Electrocardiography, functional Near Infrared Spectroscopy techniques, acquired simultaneously. We exctracted Alpha (8–13,5 Hz) and Beta (13,5–30 Hz) power rhythms with a spectral autoregressive residual model, and inter-beat-interval (RR series)...
Using a phase plane analysis (PPA) of the spatial spread of trajectories of the fetal heart rate and its time-derivative we characterize the fetal heart rate patterns (fHRP) as defined by Nijhuis. For this purpose, we collect 22 fetal magnetocardiogram using a 151 SQUID system from 22 low-risk fetuses in gestational ages ranging from 30 to 37 weeks. Each study lasted for 30 minutes. After the attenuation...
Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice. Although its mechanisms are incompletely understood, electrophysiological and structural remodeling of the atria seem to play an important role in the arrhythmia transition from paroxysmal to persistent. However, the time course of the atrial remodeling along onward episodes of non-induced paroxysmal AF has not been...
The time-series data analysis described here is based on the simple idea that the accumulation of the effects of lifestyle events, such as ingestion and exercise, could affect personal health with some delay. The delay may reflect complex bio-reactions such as those of metabolism in a human body. In the analysis, the accumulation of the effects of lifestyle events is represented by a summation of...
We have recently proposed a novel CO index, namely pulse time reflection ratio (PTRR), which is extracted from photoplethysmogram and electrocardiogram and measurable from wearable devices, and proved that this index is potentially useful for dynamic CO monitoring in a preliminary study carried out on young, healthy subjects. In this study, we presented an evaluation of this technique against impedance...
We present a novel statistical paradigm for modeling and analysis of gait variability which captures the natural point process structure of gait intervals and allows for definition of new measures instantaneous mean and standard deviation. We validate our model using two existing data sets from physionet.org. Results show an excellent model fit and yield insights into the underlying statistical structure...
The study of flow cycle morphology provides new information about the breathing pattern. This study proposes the characterization of cycle morphology in chronic heart failure patients (CHF) patients, with periodic (PB) and non-periodic breathing (nPB) patterns, and healthy subjects. Principal component analysis is applied to extract a respiratory cycle model for each time segment defined by a 30-s...
This study investigates the interplay among heart rate variability (HRV), respiration, and the severity of motion sickness (MS) in a realistic passive driving task. Although HRV is a commonly used metrically in physiological research or even believed to be a direct measure of sympathovagal activities, the results of MS-effected HRV remain mixed across studies. The goal of this study is to find the...
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