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Bivalirudin is direct thrombin inhibitor used in patients with heparin-induced thrombocytopenia. A pharmacokinetic and — dynamic model that predicts the partial thromboplastin time (PTT) based on the past infusion rates of bivalirudin following dose adjustment would be useful to guide optimal therapy. In this retrospective study we randomized 132 patients to a derivation and a validation cohort, and...
A theoretical investigation into the behaviour of the Non-Markov Parameter is performed from a signal processing perspective in contrast to previous methodologies based on stochastic processes theory. The results indicate that the NMP can be regarded as an informational metric which is indicative of the degree of low frequency synchronisation in a complex system. These results have deep implications...
An Alzheimer's fMRI study has motivated us to evaluate inter-regional correlations between groups. The overall objective is to assess inter-regional correlations at a resting-state with no stimulus or task. We propose using a generalized estimating equation (GEE) transition model and a GEE marginal model to model the within-subject correlation for each region. Residuals calculated from the GEE models...
Cardiac output (CO) change is the primary compensatory mechanism that responds to oxygenation demand. Its continuous monitoring has great potential for the diagnosis and management of cardiovascular diseases, both in hospital as well as in ambulatory settings. However, CO measurements are currently limited to hospital settings only. In this paper, we present an extension of the model proposed by Finkelstein...
Nowadays, data are recorded with increasing spatial and temporal resolution. Commonly these data are analyzed using univariate or bivariate approaches. Most of the analysis techniques assume stationarity of the underlying dynamical processes. Here, we present an approach that is capable of analyzing multivariate data, the so-called renormalized partial directed coherence. It utilizes the concept of...
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