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The majority of the population will have low back pain in their lifetime. Low back pain correlates to degenerative pain disease (DDD) which has been linked to exposure to mechanical loads. Certain occupations involving heavy lifting also correlate with DDD. Analytical models of the spine provide estimates of loading in the spine. However, data is lacking explicitly measuring mechanical forces in the...
Musculoskeletal disorders of the upper extremities, in particular the wrist and the shoulder, have become the largest class of injury in workers' compensation claims in the United States. Monitoring the development, progression, and treatment of degenerative orthopedic diseases, such as carpal tunnel and shoulder impingement syndrome, may be more effective when joint motions are assessed over long...
Self-assembled DNA supramolecules have similar dimensions and biochemical properties as natural molecules in tissues, such as collagen. Therefore, these molecules have great potential to serve as a new generation of implants. In this study, twin-based linker (TBL) nanotubes, and poly (2-hydroxyethyl methacrylate) (pHEMA) reinforced with hydroxyapatite (HA) nanoparticles (TBL/HA/pHEMA composite) were...
Low back pain is one of the leading causes of missed work. Surgical intervention is an option to those who have failed conservative therapy. The current gold standard of surgical procedures is bony fusion. Long term follow up of fusion patients has identified adjacent level disease as a complication. New motion preserving technologies aim to eliminate harmful effects on adjacent levels but have not...
Low back pain is a prevalent medical condition in the United States population. Degeneration of the intervertebral disc is associated with low back pain. The intervertebral disc is avascular and thus must receive nutrients via diffusion, primarily from the vertebral bodies through the endplates. One proposed mechanism for development of degeneration is through the sclerosis of the endplates and diminished...
High energy fractures of the tibia can frequently lead to segmental bone loss. Due to delayed fracture healing caused by poor blood flow, increased mechanical demands are placed on the fracture fixation devices, which can lead to premature failure. However, these methods have proven to be insufficient for fractures with segmental bone loss because they lack the combination of providing acute stability...
The process of bone healing is a highly orchestrated process involving mesenchymal progenitor cells (e.g., periosteal stem cells). The cascade begins with recruitment and robust proliferation of these cells followed by differentiation to osteogenic and chondrogenic cell types, which produce matrix that eventually becomes mineralized. Thus, promoting proliferation of mesenchymal progenitors is a key...
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