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Debridement is referring to the removal of the grossly contaminated and devitalized soft tissue from the wounds in the meanwhile sparing the healthy tissue. With many types of debridement available nowadays, we can perform debridement using surgical, mechanical, enzymatic, autolytic and biosurgery method . Surgical debridement is considered the fastest and effective method to clean up a wound and...
Hemoglobin content can be measured on a variety of devices. Noninvasive pulse CO-oximetry represents the latest development in hemoglobin measuring technology. The noninvasive technology and provides continuous monitoring in comparison to invasive and discrete techniques used in other methods. In addition to a summary of correlation studies, a review of the measurement principles and inherent error...
In a battlefield setting, current re-warming techniques for treating patients suffering from hypothermia are inadequate, resulting in unnecessary morbidity and mortality. The authors propose the application of heated, humidified air to a patient's airway as a complement to pre-existing hypothermia treatment techniques in order to improve this deficiency.
To avoid unnecessary preclinical testing of Covidien's hemostatic agent patch product, a test platform is needed to test the “time-to-hemostasis” of blood using the patch. The test platform needs to utilize in vitro testing, providing an alternative to in vivo testing. Understanding how “time-to-hemostasis” is affected by Covidien's various products will help surgeons prevent unnecessary bleeding...
The ability of activated leukocytes to retract pseudopods in response to fluid shear stress may be a critical mechanism to downregulate inflammation and maintain stable circulation. By measuring earlier indicators of leukocyte activation such as L-selectin shedding and β2 integrin activation, which precede morphological changes, we have found that exposure to physiological levels of fluid shear stress...
The development of individualized treatments for cancer can be facilitated by more efficient methods for separating circulating tumor cells (CTC) from patient blood in such a way that they remain viable for live cell assays. We have previously shown that immobilized P-selectin protein can be used on the inner surface of a microscale flow system to induce leukemic cells and leukocytes to roll at different...
Blood glucose measurements are vital for a wide range of medical uses, including point-of-care patient testing. Typical glucose meters have been designed to operate in controlled environments, such as hospitals, and are therefore often unsuitable for use in extreme weather conditions. This paper describes a design that will allow the glucose meter to be used in a cold weather environment, thus enabling...
A delivery system for parthenolide (PTL), a potential anticancer drug, is being developed. PTL has proved to be effective at eradicating cancer cells, such as leukemic stem cells, but its low solubility limits its use. We propose a way to circumvent this problem utilizing micelles with a hydrophobic interior that will hold the PTL and a hydrophilic exterior that will be soluble in the blood stream...
Type 2 diabetes is now the most rapidly growing form of diabetes and has become increasingly common among children. This paper presents our work of implementing an individualized real time predictive system for blood glucose in type 2 diabetes in an iPhone application. The developed application, called HealthiManage, provides relevant feedback to patients at each glucose input reading comparing the...
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