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Summary form only given. Biological systems fabricate multifunctional, high-performance materials at low temperatures and near-neutral pH with a precision of three-dimensional nanostructural control that exceeds the capabilities of present human engineering. We discovered the mechanism governing the nanofabrication of silica in a biological system, and translated this mechanism to develop a new low-temperature...
Summary form only given. A fundamental goal at the intersection of nanotechnology, immunological function and nanomedicine is the design of biologically active interfaces. Recently, we have developed both linear and conformational loop peptides on nanoclusters that mimic immunological epitopes. The nanocluster-epitope interface was studied using a quartz crystal microbalance to examine the detailed...
Summary form only given. The relentless progression and devastating ramifications of neurodegenerative diseases make symptomatic and protective treatment of these ailments particularly critical and daunting. Parkinson's Disease (PD) is characterized by severe motor impairments, significant oxidative injury and degeneration of the nigrostriatal dopaminergic neurons. Although symptomatic PD therapy...
Summary form only given. The treatment of cancer is one of the most challenging tasks of modern medicine and secondary toxicity remains a critical issue. Although intra-arterial chemotherapy or chemo-embolization provides interesting success, the release of drug in the systemic circulation prevents high intra-tumoral drug concentration to be sustained. Hence, targeting specifically the tumor cells...
Integrative technology, the merging of nanotechnology, biotechnology and informatics offers an opportunity for realizing true advances in the manner in which technology interacts with humanity. Using the power of nanotechnology to manipulate matter, that is the placing of molecule's where we want, when we want, to perform functions that we want. Using the inspiration of biotechnology both to co-opt...
Bacteria, ranging from oxygenic photosynthetic cyanobacteria to heterotrophic sulfate reducing bacteria, produce electrically-conductive appendages referred to as bacterial nanowires. Dissimilatory metal reducing bacteria, including Shewanella oneidensis and Geobacter sulfurreducens, produce electrically conductive nanowires in direct response to electron acceptor limitation and facilitate electron...
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