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A white-light source operated polymer-based micromachined Fabry-Perot chemo/biosensor is reported for the first time. It is a refractive-index sensitive optical sensor. The transducing signal varies upon the changes of the effective index of refraction in the sensing area, which is the Fabry-Perot cavity. This chemo/biosensor is made with PDMS and glass. Specifically, the micromachined Fabry-Perot...
Polypyrrole(PPy) nanowires modified electrodes were developed by template-free electrochemical method based on graphite electrode. The Ag/PPy nanowires composited modofied electrodes were prepared by method of electrochemical deposition Ag with the condition of constant current density. The electrocatalytic reduction of nitrite based on Ag/PPy nanowires composited modified electrodes was developed...
Flexible microelectrode array (MEA) has been widely used in neural prosthesis, such as artificial retinal chip. Specially, this sort of MEA for highly efficient electrical stimulation is more urgently required. In this work, a 3D flexible parylene-metal structure was fabricated by structure transfer technique. Silicon wafer was etched by deep reactive ion etching and isotropic wet etching sequentially...
Parylene nanomechanical cantilevers with integrated piezoresistors were proposed for biochemical sensing based on surface-stress measurement. By using polymer as the cantilever material, the sensitivity is significantly increased. Simultaneously, parylene piezoresistive cantilevers exhibit different behaviors compared with their more rigid counterparts. Therefore new design guidelines need to be developed...
In this paper, we present a method for fabricating parylene films with different features. It has been reported that transitional metals, such as Au, have an inhibitive effect on the growth of parylene. By utilizing this property, we deposit parylene on different Au-coated surface and achieve special parylene films, including polycrystalline-like film and ldquonano-hillrdquo film. We have taken some...
A novel microfluidic platform is presented for sorting by size dissociated neurons, glia and stem cells from biopsies of the central nerve system. A highly biocompatible aqueous polymer solution was used in hydrodynamic spreading controlled cell separation. Before cell separation, particles were used for demonstration. To verify the results the fractions were studied using flow cytometry. Further,...
Novel micro- and nanotechnologies enable translational engineering solutions for next generation therapies to address vital unmet medical needs. In particular, they are uniquely suited to address challenges in achieving highly effective drug delivery central to the management of incurable diseases. Our research focuses on the application of microelectromechanical systems (MEMS) fabricated from biocompatible...
Bovine pancreatic trypsin conjugates were first synthesized using succinoylated beta-cyclodextrin and succinoylated PAMAM dendrimer. Their conjugates had a trypsin content of 72 and 50 wt%, respectively. The trypsin activity of conjugates measured by using Nalpha-benzoyl-D, L-arginine-p-nitroanilide hydrochloride (BAPNA) as substrate was decreased by polymer conjugation. The kinetic parameters (KM...
Nanofibers will be of great use in tissue engineering, filtration, protective clothing and micro/nano devices etc. In this paper a facile method is introduced to traditional electrospinning to deposit patterned nanofibers to expand its applications, in which three types of parallel top-bottom configurations of two different materials, that is, plastic (polyethylene terephthalate, PET)-glass, plastic-copper...
This study develops an improved method for generating aluminum mold inserts used in the replication of polymer-based microfluidic chip. Since molding masters that are suitable for microfluidic chip replication must have features whose dimensions are of the order of tens to hundreds of microns, micro electrical discharge machining is employed herein to fabricate an aluminum mold insert of a microfluidic...
To make significant progress in the fight against cancer, treatment should target cells more specifically, produce fewer side effects, be easy to administer and deter tumor viability on multiple levels. We have attained dramatic in vivo tumor shrinkage and tumor vasculature disruption using a ternary biomolecular nanoparticle comprised of polymeric carrier polysaccharide heparin, anticancer drug retinoid...
Bismaleimides with three prepolymer molecular weights were synthesized and fabricated into graphite fiber reinforced nano-SiO2 composites. Thermo-oxidative stability of these nano-composites under short-term isothermal exposure was studied. These composites were exposed to isothermal ageing for up to three hours. Dynamic mechanical properties and weight loss measurements indicate that for the composite...
Superhydorphilic polyester film has been obtained by oxygen plasma treatment to maintain optical clarity under high relative humidity. The original and treated films are simultaneously exposed to the vapor from hot water. The latter keeps its optical clarity because the condensed water formed a thin film on it instead of droplets for the former. Compared with the widely used coating method, plasma...
Presently, inexpensive hand-held corona system has been widely used as an alternative for PDMS-PDMS bonding, considering the fact that it is both effective and highly portable. In the present work, to optimize this corona-triggered bonding technique, different PDMS curing conditions and corona exposure time have been tested. The hydrophobic recovery of the corona treated PDMS surface was quantitatively...
The microstructure of Si3N4/SiC derived from the pyrolysis of UV curable polymer ceramic precursor was analyzed and characterized by TGA-DTA, XRD, FE-SEM, Electron Spectrometer, and TEM. It was found that two distinct weight loss rate peaks at 358degC and 450degC in TGA curve were identical with two DTA endothermic peaks. The total weight loss was 45wt%. The degree of crystallinity reached 91.25%...
A novel electrowetting on dielectric (EWOD) digital microfluidic device using the high dielectric constant material P(VDF-TrFE) (poly-vinylidene fluoride-trifluoroethylene) as the dielectric layer fabricated by spin-coating process is proposed. The device is featured with the advantages of both IC compatible process and low driving voltage. The contact angle between the liquid droplet and surface...
In this paper, we present microfabrication of a novel photopatternable conductive PDMS material with silver powder as conductive filler and benzophenone as photosensitive component, employing standard photolithography approach. An array of miniaturized capacitive pressure sensors is micromachined onto flexible polymeric transparency using this approach. Highest conductivity of ~104 Sldrm-1 and minimal...
The realization of the biosensing platform could be achieved via the measurement of evanescent wave absorption by the nanoparticle-modified optical fiber. The present microfluidic device was made of polymethylmethacrylate (PMMA) by microinjection molding. The reaction microchannel is 950 mum high and 950 mum wide with an effective binding length of 18.1 mm. An unclad optical fiber of 400 mum in diameter,...
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