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We developed reaction chamber arrays with a volume of a few femtoliters to monitor biological reactions at single-molecule level. Micro-meter holes were fabricated on the surface of a silicone elastic sheet (PDMS). Sample solutions were sandwiched between the fabricated sheet and a glass surface. Resultantly, solutions were enclosed in each chamber hermetically. The uniformly shaped chambers allow...
Nanodiamond materials can be engineered for a broad range of applications in medicine. This presentation will highlight the relevance of these materials as foundations for device fabrication across the spectrum of biology and technology. We have applied diamond-based nanomaterials toward controlled and localized drug delivery for applications in anti-inflammation to protect against implant rejection,...
Nanotechnology will allow us to build devices enormously smaller than before and will bring fundamental changes to the disciplines such as engineering, chemistry, medicine, biology, and physics. The research in nano manipulation and nano assembly is tremendously important because most physical magnitudes characterizing nano scale systems significantly differ from those familiar in macro, meso, and...
In this work, we demonstrate a novel SU8/SiO2 /PMMA trilayer nanoimprint technique to fabricate the silicon nanowire (SiNW) sensor used for gas detection. The SiNW sensor fabricated in our experiment is based on the silicon on insulator (SOI) substrate which is doped by boron with a dopant concentration of 8 times 1017 cm-3. Two nanowire sensors with different linewidths as well as a thin-film plane...
The System-on-a-Chip (SoC) exhibits great promise in the world of microelectronics, while LOC (Lab-on-a-Chip) contributes a great progress for biochemical research. A combination of the semiconductor integrated SoC with LOC is brought in this presentation. We propose a new technology which enables monolithic integration of the self-assembled biological system, the MEMS structure, the microfluidic...
In many modern fields of life science research the nanometer scale becomes of increasing importance. This is in no contradiction to the strong trend of treating complex biological entities, such as cells, as complete systems that have to be understood as a whole and in the context of complex interactions with their environment. While this system approach clearly goes beyond traditional concepts of...
In this paper nanomachining on aluminum film using an atomic force microscope (AFM) with commercial diamond tip is investigated. To obtain nano scale groove structure, experiments of nanomachining on aluminum films under various machining conditions were conducted. Then the cross sections of the grooves were measured by AFM, which indicates that using diamond tip, deep grooves on the aluminum film...
Based on DEP manipulation of CNTs, our group has, in the past few years, systematically developed a time-efficient approach to engineer CNT based sensors, i.e., only ∼1sec is required per CNT sensing element. Some examples of CNT devices fabricated with this technology includes MEMS pressure sensors, chemical sensors, and flow shear stress sensors. In this talk, we will focus our discussion on the...
Antibiotics susceptibility testing is often performed to determine the antibiotic resistance of pathogenic agents in clinical samples, such as urine or wound specimens. Rapid determination of antibiotics susceptibility is crucial towards judicious management of infectious diseases, especially in emergency situations and high-risk areas such as hospitals, rural clinics, and temporary clinics established...
Advancement in the field of nanorobotics has been facilitated by the current advances in nano-bio-technology and nanofabrication methods. The important uses of nanorobots are in advancing medical technology, healthcare and environment monitoring. In bio-medical applications, nanorobots need to swim in biological fluids flowing in narrow channels of few hundred nanometer size. The dominating effects...
We present modeling results of a novel nanomechanical cantilever sensor using optical nanocavity resonator. A nanocavity resonator comprises two-hole pairs which are placed along a U-shaped silicon waveguide at the edge of cantilever. The resonant wavelength of output spectrum is sensitive to the shape of air holes and defect length of the nanocavity resonator. The minimum detectable strain, vertical...
Presently, with the development of nanofabrications, patterning nanoparticles into monolayer attracts tremendous interests. In this work, a microfluidic-assisted nanoparticle monolayer patterning approach was proposed to produce noncontinuous patterns based on the well-known continuity equation in fluid mechanics. Soft-lithography used in this approach greatly reduced the cost and time of the fabrication...
A novel phenomenon about silicon nanowire(SiNW) is discussed here, which is related to its self-alignment characteristic when a temperature gradient field appears assisted by electric field. For the SiNW grown by vapor-liquid-solid method, it suffers an alignment force when its two terminals' temperature is different. Experiments about this effects have been observed and it has been anticipated that...
This paper reports a multi-walled carbon nanotube (MWNT) cluster-based process for removing bacteria by uniquely combining the two excellent properties of carbon nanotubes (CNTs): magnetic susceptibility and bacterial affinity. The reaction system consisted of large clusters of MWNTs for bacterial capture and an external magnet for bio-separation. The designed system was tested using four different...
The process parameters that influence the performance of nano-size hydroxyapatite powder such as purity, granularity, and crystallinity include the mass ratio between Ca(NO3)2middot4H2O and (NH4)2HPO4, the PH value of reaction liquid, the temperature of sintering and the time of heat preservation. Orthogonal experiments with different process parameters are designed; experiments were carried out with...
The involvement of nanotechnology in biology, biomedical devices, and analytical sciences provides tantalizing opportunities to miniaturize biosensing platforms for applications in diagnostics, biotechnology, environmental monitoring, pharmaceutical research, and research in life sciences at large. Key for realizing these opportunities is the accurate patterning of protein receptors on surfaces and...
Assembly of colloidal arrays has attracted much attention over the past decade. Surface property and topology play important roles in the assembly of colloidal patterns and layers on various substrates. In this paper, we report on a novel micropattern-assisted nanoassembly (muPAN) method to organize highly ordered nanocolloidal arrays onto a nonfouling polymer surface. Polyethylene glycol (PEG) hydrogel...
A strain k.p model is used to investigate lattice temperature dependence of the piezoresistivity of p-doped silicon nanobeam sensor in the range of 100-600 K based on the self-consistent solution of the Schodinger and Poisson equations. Based on quasiharmonic approximation, an analytical semi-continuum model is presented to describe the effect of size and temperature on elastic constants of the silicon...
We present an optomagnetic tweezers technique that utilizes the highly localized magnetic field gradients generated near the tip of a magnetic nanowire to provide strong trapping forces on magnetic nanoparticles with high spatial resolution. Integral to the approach is a method to trap, translate, and rotate a single magnetic nanowire in three dimensions; this nanowire is in turn capable of exerting...
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