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In this paper, we present two designs for developing a biocompatible affinity MEMS glucose sensor. Based on these designs, two devices were fabricated and characterized. These devices, consisting of a micro-cantilever or membrane situated inside microchambers, are driven by a remote magnetic field and separated from the sensing environment by a semi-permeable membrane. A change in viscosity induced...
This paper reports the completion of fundamental fluidic operation considered essential to build digital microfluidics system, which can be used for micro total analysis system (mu-TAS) or lab-on-a-chip by the coplanar electrode type of EWOD device. Coplanar electrode type of EWOD chip could be designed as a novel tool to delivery many kinds of bio-samples, such as DNA, enzyme, and salt solution without...
Cancer and many other diseases are characterized by changes in cell morphology, motion and mechanical rigidity. However, in live-cell-cytology stimulus-induced morphologic changes typically take 10–30 minutes to detect. Here, we employ live-cell-interferometry (LCI) to visualize the instantaneous response of a whole cell to mechanical stimulation, and we detect cytoskeletal remodeling behavior within...
A novel optical biosensor with gold surface bound silver nanoparticles has been constructed for detection of bio-molecules like antigen, antibody protein and DNA plasmid, which exhibited distinct optical properties of localized surface plasmon resonance (LSPR). The silver colloidal nanoparticles were prepared by using sodium borohydride reduction of silver nitrate and characterized by using UV-vis...
Bovine pancreatic trypsin conjugates were first synthesized using succinoylated beta-cyclodextrin and succinoylated PAMAM dendrimer. Their conjugates had a trypsin content of 72 and 50 wt%, respectively. The trypsin activity of conjugates measured by using Nalpha-benzoyl-D, L-arginine-p-nitroanilide hydrochloride (BAPNA) as substrate was decreased by polymer conjugation. The kinetic parameters (KM...
The ingestion of some organic compounds has been known to lower the risk of cancer. With emerging studies in the past decade, the biological effect of these compounds has been recognized within a clinical context and presents an appealing strategy for cancer prevention. These compounds, now commonly referred as chemopreventive agents or anti-carcinogens, often exert their activity by inducing expression...
Diffusion is often the rate-limiting step in microfluidic-based biochemical analysis systems. In this paper, an alternative current electrothermal mixer for molecular diagnostic is presented. The mixer consists of a concentric electrode design integrated in a microfluidic cartridge. We investigated the electrothermal flow by visualizing the trajectories of seeded particles. The velocity shows a fourth...
This work presents the design, fabrication and experiments of a new blood-filtering chip based on SU-8 and PDMS. The main function of this blood-filtering chip is to filter the leukocyte out of the blood. This new leukocyte filtered chip is composed of three parts: cover plate, filtering plate and receiving plate. The shape of the transfusing channel is optimized by simulation. The new blood-filtering...
Enzyme free glucose micro-biosensors with nanoporous platinum (Pt) electrode were fully packaged with biocompatible Nafion membrane and characterized in bio-fluidic solutions. Three different packaging methods which were a dip coating, spin-casting, and chemical bonding were applied, characterized, and compared to find an optimal one for anti-fouling of protein in bio-fluidic solution. In human plasma...
The realization of the biosensing platform could be achieved via the measurement of evanescent wave absorption by the nanoparticle-modified optical fiber. The present microfluidic device was made of polymethylmethacrylate (PMMA) by microinjection molding. The reaction microchannel is 950 mum high and 950 mum wide with an effective binding length of 18.1 mm. An unclad optical fiber of 400 mum in diameter,...
This paper reports a rapid, simple and direct method for the synthesis of gold nanoparticles (AuNPs) in polypyrrole (PPy) film, which provides a biocompatible matrix for the strong adsorption of antibodies. The electrochemical synthesis of AuNPs/PPy composite on gold or carbon electrode occurs within 20 minutes, and does not involve addition of any nanoparticles or reducing agent. This method is compatible...
Use of this work proposes a novel technique to induce the attachment of tumor cells to the micropatterns of glutaraldehyde (GA)-crosslinked gelatin. It provides another method to crosslink gelatin other than using the photo-sensitizing agents or selective GA-crosslinked technique. The micropatterns of GA-crosslinked gelatin are fabricated by O2 plasma etching process. This novel technique can ensure...
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