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This paper describes the design of silicon intracortical stimulating microelectrodes for mapping of the functional organization in the central nervous system and potential neural prosthetic applications. Active microelectrodes with different configurations have been developed to facilitate various applications. In-vivo experiments were conducted in selected areas (auditory cortex, DCN, IC) in the...
A novel architecture to realize a low-power, low-noise amplifier for cortical neural prostheses is presented. The design consists of a low-noise variable gain amplifier as the first stage, a low-Gm high-pass filter as the second stage, and a low-pass Gm-C amplifier as the last stage. Discrete-time autozeroing is utilized to reduce the offset and noise. The bandwidth and autozeroing frequency of the...
An auto-zero (AZ) technique to cancel offset and drift in a bio-implantable integrated circuit is discussed in this paper. The implemented circuit is designed for monitoring blood pressure of transgenic mice. Due to small available volume, the power consumption is the primary design issue. In order to reduce the power consumption, techniques at the system level as well as circuit level are used. The...
The efficiency of implantable stimulation systems depends in large proportion of the electrode-tissue interface condition and in the choice of appropriate stimuli waveform. In this paper, we present an integrated flexible stimuli generator dedicated for high current stimulation in large electrode-tissue contact impedance. The system, powered by a single 3.3 V supply level, includes an integrated high...
The paper presents a novel transimpedance amplifier to sense very small and fast biological signals even in the presence of a dc leakage current as high as few tens of nanoamperes. The circuit, integrated on standard 0.35 mum CMOS technology, has a core based on the series of an integrator and a differentiator stage but features an additional time continuous feedback loop to discharge the standing...
A micro-power transimpedance amplifier is presented to acquire modulated optical signal for heart-rate measurement. The circuit is composed of a transimpedance amplifier (TIA), a sample-and-hold (S/H) circuit, an error amplifier and a current-sink transistor, configured in a feedback loop to reject DC photocurrent generated from photodiode, which varies from person to person. To reduce power consumption,...
This paper describes a chip design technique for body composition analyzer based on the BIA (bioelectrical impedance analysis) method. All the functions of signal forcing circuits to the body, signal detecting circuits from the body, Micom, SRAM and EEPROMs are integrated in one chip. Especially, multi-frequency detecting method can be applied with selective band pass filter (BPF), which is designed...
A Sigma-Delta (SigmaDelta) modulator with 10 bits of resolution and only 55 nW power consumption for electroencephalogram (EEG) applications is presented. The overall modulator operates from 1.2 V using Quasi-Floating-Gates (QFG) based circuits. The system has been implemented in a standard 0.5-mum CMOS process. Post-layout simulations have been performed showing 70 dB of SNR with an oversampling...
This paper presents a time-multiplexed architecture of a wavelet based event detector for cardiac rhythm management devices. The architecture of a previously in an ASIC implemented event detector serves as a reference, and is folded in order to minimize area and leakage. Simulation results prove that leakage and dynamic power of the entire design is reduced by more than 30 %, whereas area decreases...
Current-mode log-domain CMOS filters have favorable properties, such as wide dynamic range at low supply voltage, compactness, linearity and low power consumption. These properties are becoming increasingly important for biomedical applications that require extremely low-power dissipation and neuromorphic circuits that attempt to reproduce the biophysics of biological neurons and synapses. We present...
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