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Computational methods for describing, understanding, and manipulating biological pathways continue to be a heavily researched area. Many researchers use constructs based in electrical circuit design in the modeling and analysis of biological systems, but few draw on and exploit parallels between electrical circuits and biological circuits for simulation purposes. We develop a biological simulation...
Recent advances in homologue recombination based bacterial artificial chromosome (BAC) engineering have greatly simplified knock-in, knock-out and random integration based transgenic mice technologies. Despite the rapid advances in ldquowetrdquo BAC engineering, efficient bioinformatics tools for choosing the appropriate BACs and designing the targeting construct with gene specific homology arms has...
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