The implementations of the safety measures in the handling port operations mainly focus on the safety and reliability of handling equipment. Limit switches and sensors are installed on the handling equipment to ensure the operation safety, but the characteristics of the workers, the dynamic and the intersectional production state which is composed of many factors, man, machine, environment and so on, were ignored. For the high mobility and high risk of the port workers, the dynamic monitoring and the management of the workers on site cannot be carried out with existing technology. To ensure the safety of the ground workers in dangerous port operation areas, a new port ground workers monitoring and safety warning system based on the radio frequency identification (RFID), internet of things, and intelligent alarm technology was put forward in this research. It can provide the real-time, dynamic monitoring for workers on site in case of the danger. In this paper, the system architecture of the wearable data acquisition device, the data processing equipment and the remote monitoring & control center were analyzed. The research achievement in this paper was applied in a port and good results were obtained.