The last decade has seen an explosion in research efforts which attempt to miniaturize rack-mounted, neural interface electronics to a form that is easily implantable for in vivo applications. Commensurate with this trend, neural scientist and engineers are demanding higher performance electronics for neural stimulation, recording, encoding, communication and energy harvesting, all in the context of a closed-loop neural interface. Single-chip integration of all the desired electronics appears to be the obvious solution for practical Bidirectional Brain Computer Interfaces (BBCI). However, challenges remain to realize a closed-loop neural interface which must utilize minimal energy, produce high voltages and suppress unwanted spurious signals which are created by “simulation artifacts.” This presentation will start with an overview of integrated neural interface electronics and conclude with a description of some recent work conducted at University of Washington's Center for Sensorimotor Neural Engineering (CSNE).