In this paper, a high isolation MIMO filter antenna based on the coupled transmission line resonant structure is proposed. There are two controllable transmission zeros in the coupled transmission line resonant structure. Based on the characteristic, slot filter antenna with high frequency edge selectivity is designed. Then through slotting and the introduction of decoupling of tree structure on the floor, it makes two port isolation reach more than 15dB. The designed MIMO filter antenna has the advantages of compact structure, good frequency selectivity, high isolation degree.