Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) allows approaching the peritoneal carcinomatosis, final stage of cancer, in a therapeutic manner. The commercially available HIPEC devices have some shortcomings, thus the authors intend to develop an affordable HIPEC equipment that surpasses the drawbacks of existing devices. HIPEC equipment needs to maintain a homogenous temperature for the cytostatic solution of 42°C through the peritoneal cavity, thus, a temperature control structure is mandatory. Authors present in this paper the design of two cytostatic solution's temperature control structures, with a neural network controller and an Internal Model Control (IMC) controller. Both controller design methods use the heating process model, and in addition this paper presents a comparison between the two control structures, from the point of view of simulated step response performance set.