The lifetime-limiting failure mechanisms of CuInGaSSe (CIGSS) solar devices made by Shell Solar Industries (SSI) were investigated. In our study, SSI minimodules were exposed to dry-heat 85??C, damp-heat 85??C/85% RH and aerobic and anaerobic room temperature and 85??C water baths. After 200 hours exposure to moisture-containing environments, the average device performance decreased by more than 30% that of the initial state. The observed degradation was primarily due to losses in short circuit current density (Jsc) and fill factor (FF). The as-received device layers were relatively dense and free of voids. Interestingly, unreacted Cu-Ga particulates were found at the Mo-CIGSS interface. Corresponding with these particulates, CIS-rich defects were found within the bulk CIGSS material. Post-environmental weathering, Kirkendall-like voids were found in the Al:ZnO and CdS layers of these devices. Additionally, ToF-SIMS analysis revealed the Cu-Ga/CIS defects were enriched in Na and O. Our results indicate that in addition to moisture-induced failure of the window layers, the unreacted Cu-Ga particulates and the corresponding CIS-defects may facilitate moisture and/or oxygen-induced failure of these devices.