The design of a compact low-power highspeed class-AB buffer amplifier for driving the large column line loads of large-size TFT-LCD is presented in this paper. The class-AB buffer amplifier can drive large column line loads up to lOOOpF within 1.28 mus. The proposed class-AB buffer amplifier is implemented with a standard 0.35 mum CMOS 2-poly 4-metal process technology and simulated using HSPICE. The measurement results show that the power consumption of 25.67 muW, and exhibits the slew rates of 4.5V/ mus and 5V/ mus for rising and falling edges, respectively, under a lOOOpF load. The active area of this class-AB output buffer amplifier is only 47 x 45 mum2.