Bullous pemphigoid (BP) is an autoimmune blistering disorder characterised clinically by tense blister formation and immunologically by the presence of tissue bound and circulating anti-basement membrane zone (BMZ) antibodies. The aim of the study is to investigate the relationship between clinical features and BP antigens. Clinical and laboratory findings were collected for 100 BP patients. Correlations between the clinical findings and antigen profiles were statistically analyzed (Mann-Whitney and Chi-Square). We divided the patients into four groups based upon the results of immunoblot analysis, namely patients whose sera detected both the 230kD BP antigen (BP230) and the 180kD BP antigen (BP180), those recognising either BP230 or BP180 and those recognising neither antigen. Chi-square tests showed a predominant occurrence of oral and facial lesion in patients whose sera detected BP180, and these patients also tended to have more extensive lesions. The Mann-Whitney test indicated that the patients that were positive for BP180 alone, needed treatment with higher doses of steroids than the patients positive for BP230 alone. Furthermore, all 5 recalcitrant cases, which did not respond well to steroid treatment, were shown to possess auto-antibodies against BP180 in their sera. Disease severity correlated to the WBC count, the eosinophil percentage and the IgE value but did not correlate to the anti-BMZ antibody titre. Patients detecting BP230 had a tendency to have a high titre of anti-BMZ antibodies. These results suggest that anti-BP180 antibodies may be more related to disease severity than anti-BP230 antibodies.