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Direct effects of the enantiomers of the classical dopamine receptor ligand apomorphine on 5-HT 3 receptors were examined in N1E-115 neuroblastoma cells in whole-cell voltage clamp mode. R(-)-apomorphine (R(-)APO; 3-300 μM) evokes a small, transient inward ion current. At 30 μM, R(-)APO induces its maximum inward current, which is approximately 3% of the amplitude of the inward current induced...
The effects of apomorphine on the striatal l-[ 11 C]DOPA influx rate was examined in anaesthetized Rhesus monkeys using positron emission tomography (PET). In comparison with baseline conditions, the addition of a continuous infusion of apomorphine produced decreases in the striatal l-[ 11 C]DOPA influx rate in all the monkeys examined. The effect of apomorphine infusion...
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