Biogas production from cattle manure (CM) is of growing importance as it offers considerable environmental benefits. The supplementation of palm oil mill effluent (POME) in anaerobic digestion of CM can be beneficial as it provide a source of energy, while simultaneously resolving ecological and water pollution. Biogas production was investigated in a 10 L bioreactor operated in batch and semi-continuous mode at 53 o C. An enhanced biogas yield of 0.346 m 3 kg -1 VS added was observed from the CM with POME digestion, while the biogas production is not higher when CM was digested alone. Also, the VS and COD reduction for CM with POME digestion were 69 and 65% higher than raw CM digestion. The results showed that valid contribution has been done by the use of POME.