Systematic interventions are being planned and progressively designed on most buildings of the Arsenale of Venice, the Venetian republic’s shipyard, a very large complex of docks and sheds of peculiar construction characteristics. These renovation interventions are required in view of new uses for the revitalizing of that area, which is currently almost completely neglected. In the paper, after a general presentation of the main properties and of the most relevant deterioration phenomena of the principal parts of the monumental area, the methodology that is being used for the structural diagnosis, for the implementation of guidelines for the future interventions and for the maintenance of the restored conditions are presented. Some preliminary results, given by experimental tests performed both in situ and in laboratory on materials and structural elements, and by FE simulations, are discussed.