The performance of a new electro-Fenton process with Ti-based mixed metal oxides (Ti/MMO) cathode, a dimensionally stable electrode, is evaluated for degrading contaminants of emerging concerns (CECs) in aqueous solutions. Bisphenol A (422μgL −1 ) is completely degraded in an undivided cell using Ti/MMO as the cathode in the presence of 6.9mgL −1 Fe 2+ within 20min under conditions of pH 4 and 25mA. Both bisphenol A degradation and H 2 O 2 production increase with decreasing solution pH and increasing current. Ti/MMO cathode is effective for reducing O 2 to H 2 O 2 and regenerating Fe 2+ from Fe 3+ . OH radicals are validated to be the predominant reactive oxygen species (ROS) contributing to bisphenol A degradation. This new electro-Fenton process is also effective for degrading bisphenol A, triclosan and ibuprofen even at a relatively high concentration of 5mgL −1 . The partial removals of total organic carbon suggest a moderate extent of mineralization. The transformation pathways of the three CECs are proposed based on the intermediates identified by HPLC and GC–MS, showing that CECs are mainly transformed to nontoxic aliphatic acids. This study demonstrates that Ti/MMO can be used as the cathode in the electro-Fenton process for degrading CECs at trace levels in waters.