Serwis Infona wykorzystuje pliki cookies (ciasteczka). Są to wartości tekstowe, zapamiętywane przez przeglądarkę na urządzeniu użytkownika. Nasz serwis ma dostęp do tych wartości oraz wykorzystuje je do zapamiętania danych dotyczących użytkownika, takich jak np. ustawienia (typu widok ekranu, wybór języka interfejsu), zapamiętanie zalogowania. Korzystanie z serwisu Infona oznacza zgodę na zapis informacji i ich wykorzystanie dla celów korzytania z serwisu. Więcej informacji można znaleźć w Polityce prywatności oraz Regulaminie serwisu. Zamknięcie tego okienka potwierdza zapoznanie się z informacją o plikach cookies, akceptację polityki prywatności i regulaminu oraz sposobu wykorzystywania plików cookies w serwisie. Możesz zmienić ustawienia obsługi cookies w swojej przeglądarce.
Medicine Branch, National Cancer Institute, Rockville, MD 20850, USA SciClone Pharmaceuticals, San Mateo, CA 94404, USA Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC 20037, USAThe effects of thymosin (THN) α1 were investigated using the urethane injection carcinogenesis A/J mouse model. Lung adenomas were observed 2.5, 3, and 4 months after urethane injection (400 mg/kg i.p.) into female A/J mice. Daily administration of THNα1 (0.4 mg/kg, s.c.) reduced lung adenoma multiplicity significantly, by approximately 45, 40, and 17%, respectively, 2.5, 3, and 4 months after urethane injection. Animals treated with THNα1 had a significantly greater white cell density than control A/J mice. Endogenous THNα1-like peptides were detected in the mouse lung. By radioimmunoassay and by Western blot, prothymosin α was detected in the mouse lung. By immunocytochemistry, THNα1-like peptides were detected in all lung compartments including the bronchus, adenoma, bronchioles, and alveoli. These results indicate that exogenous THNα1 prevents lung carcinogenesis in A/J mice.Thymosinα1Lung adenomasChemopreventionA/J mice
Medicine Branch, National Cancer Institute, Rockville, MD 20850, USA SciClone Pharmaceuticals, San Mateo, CA 94404, USA Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC 20037, USAThe effects of thymosin (THN) α1 were investigated using the urethane injection carcinogenesis A/J mouse model. Lung adenomas were observed 2.5, 3, and 4 months after urethane injection (400 mg/kg i.p.) into female A/J mice. Daily administration of THNα1 (0.4 mg/kg, s.c.) reduced lung adenoma multiplicity significantly, by approximately 45, 40, and 17%, respectively, 2.5, 3, and 4 months after urethane injection. Animals treated with THNα1 had a significantly greater white cell density than control A/J mice. Endogenous THNα1-like peptides were detected in the mouse lung. By radioimmunoassay and by Western blot, prothymosin α was detected in the mouse lung. By immunocytochemistry, THNα1-like peptides were detected in all lung compartments including the bronchus, adenoma, bronchioles, and alveoli. These results indicate that exogenous THNα1 prevents lung carcinogenesis in A/J mice.Thymosinα1Lung adenomasChemopreventionA/J mice
Medicine Branch, National Cancer Institute, Rockville, MD 20850, USA SciClone Pharmaceuticals, San Mateo, CA 94404, USA Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, DC 20037, USAThe effects of thymosin (THN) α1 were investigated using the urethane injection carcinogenesis A/J mouse model. Lung adenomas were observed 2.5, 3, and 4 months after urethane injection (400 mg/kg i.p.) into female A/J mice. Daily administration of THNα1 (0.4 mg/kg, s.c.) reduced lung adenoma multiplicity significantly, by approximately 45, 40, and 17%, respectively, 2.5, 3, and 4 months after urethane injection. Animals treated with THNα1 had a significantly greater white cell density than control A/J mice. Endogenous THNα1-like peptides were detected in the mouse lung. By radioimmunoassay and by Western blot, prothymosin α was detected in the mouse lung. By immunocytochemistry, THNα1-like peptides were detected in all lung compartments including the bronchus, adenoma, bronchioles, and alveoli. These results indicate that exogenous THNα1 prevents lung carcinogenesis in A/J mice.Thymosinα1Lung adenomasChemopreventionA/J mice