The aim of this study was to determine the effect of different dying methods, such as convective drying (CD: 50, 60, 70°C), vacuum-microwave drying (VMD: 120, 480, 480–120W), a combination of convective pre-drying and vacuum-microwave finish drying [(CPD (60°C)-VMFD (480–120W)], and freeze-drying (FD) on key quality parameters of dried jujube fruits (cv. “GAL”, “MSI”, and “PSI”). The parameters studied included bioactive compounds (flavan-3-ols and flavonols, identified by LC-PDA-MS, and vitamin C), antioxidant capacity (ABTS and FRAP), and sensory attributes (e.g. hardness, jujube-ID, and sweetness). The best quality of the dried product (high contents of bioactive compounds and high intensity of key sensory attributes) was found in fruits treated by FD and VMD 480–120W. The best cultivars were “PSI” and “GAL” from the point of view of bioactive content and sensory quality, respectively.