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We investigate the role of nitric oxide (NO) in the hypersecretion of acid and pepsinogen induced by stomach distension.The rat stomach was distended by instillation of saline through an acute fistula under urethane anesthesia.Both secretions of acid and pepsinogen were increased by the distension depending on the volume of saline introduced, and responses were attenuated by bilateral cervical vagotomy...
Low concentrations of nitric oxide (NO) produced by constitutive NO synthase (cNOS) in pancreatic β-cells have been suggested to be a physiological regulator of insulin secretion. In contrast, excessive NO produced by inducible NO synthase is known to mediate β-cell apoptosis. The aim of the present study was to investigate the effect of low concentrations of NO on β-cell apoptosis.Apoptosis of the...
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