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This study investigates the proliferative effect of adenosine (ADO) in cultured mesangial cells, and the possible mediation of A 1 and/or A 2 receptors in this proliferative effect of ADO. ADO (10 −5 M) induced a significant increase in the [ 3 H]thymidine incorporation into DNA with respect to quiescent cells. This increase was similar to that obtained with the ADO...
One attractive candidate for a Ras effector protein, other than the Raf kinases, is Ras-GAP. Indeed, recent literature suggests that besides the Raf/MAP kinase cascade, additional pathways must be stimulated to elicit a full biological response to Ras. Ras binds the COOH terminal domain of Ras-GAP, while the NH2 terminal domain appears to be essential for triggering downstream signals. Since Ras-GAP...
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