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One attractive candidate for a Ras effector protein, other than the Raf kinases, is Ras-GAP. Indeed, recent literature suggests that besides the Raf/MAP kinase cascade, additional pathways must be stimulated to elicit a full biological response to Ras. Ras binds the COOH terminal domain of Ras-GAP, while the NH2 terminal domain appears to be essential for triggering downstream signals. Since Ras-GAP...
Intracellular expression of antibody can interfere with the cell function of targeted molecules and has a vast clinical potential in cancer therapy. A scFv fragment, Y259, has been derived from the anti-p21 ras rat MoAb Y13-259, by a three-step method using mouse primers cross-hybridizing with rat BH and Vk sequences and with linker (gly4.ser)3-encoding complementary oligonucleotides...
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