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Variations in T-cell activation Rho-GTPase activating protein (TAGAP) have been associated with various autoimmune diseases including Rheumatoid Arthritis (RA). The gene is involved in T cell activation and is therefore of particular interest in context of T cell-driven autoimmune diseases. Genome-wide association studies suggest association between TAGAP and RA in various populations. This study...
Previous studies suggest that miR-146a rs2910164 and miR-499 rs3746444 polymorphisms are associated with susceptibility to pulmonary tuberculosis, but the reported findings are inconsistent. We conducted this meta-analysis to evaluate the relationships between the two single nucleotide polymorphisms and tuberculosis.Potentially relevant studies were identified by searching PubMed and Embase databases...
Matrix metalloproteinases (MMPs) play a fundamental role in tissue degradation or remodeling and involved in all stages of tumor progression. However, the role of the MMPs polymorphisms with endometrial carcinoma has not been fully examined in Egyptian patients. Therefore, we planned this study to evaluate associations of the MMP-1 (−1607 1G/2G) and MMP-3 (−1171 5A/6A) polymorphisms and their immune...
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