A vast sheet of mature quartz sand blanketed north Africa and Arabia from the Atlantic coast to the Persian Gulf in Cambro–Ordovician times. U–Pb geochronology of a representative section of Cambrian sandstone in southern Israel shows that these sediments are dominated by 550–650 Ma detrital zircons derived from Neoproterozoic Pan-African basement. The short time lag between magmatic consolidation of a Pan-African source and deposition of its erosional products indicates that, despite their significant mineralogical maturity, the voluminous quartz-rich sandstones on the northern margin of Gondwana are essentially first-cycle sediments.Mass production of these voluminous first-cycle quartz-rich sandstones resulted from widespread chemical weathering of the Pan-African continental basement. We suggest that conditions favoring silicate weathering, particularly a warm and humid climate, low relief and low sedimentation rates prevailed over large tracts of Gondwana in the aftermath of the Pan-African orogeny. An unusually corrosive Cambro–Ordovician atmosphere and humid climate enhanced chemical weathering on the vegetation-free landscape. We infer that late Neoproterozoic–Cambro–Ordovician atmospheric pCO 2 rose as a consequence of widespread late Neoproterozoic volcanism, followed by an uptake of CO 2 by chemical weathering to produce the Cambro–Ordovician sandstone as a negative feedback.