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The balance between specific and degenerate T cell recognition of MHC class II bound peptides is crucial for T cell repertoire selection, and holds important implications for protective immunity versus autoimmunity. To investigate the degree of degeneracy in T cell recognition, we applied selected modifications to T cell receptor (TCR) contact residue amino acids in the MHC class II bound epitope...
Degeneracy of recognition of antigen by the immune system is being used as an argument that the self–nonself discrimination cannot be a property of the specificity of its antigen-receptors, TCR and BCR, but must rely on emergent properties derived from a set of complex interactions and pathways. This essay analyzes an alternative view by showing that degeneracy and specificity are not mutually exclusive...
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