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The synthesis, NMR and X-ray analysis of tris(1-ethyl-2-isopropylimidazol-5-yl)phosphine gold(I)-2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranoside, a bifunctional auranofin analogue
A derivative of auranofin, a drug used in the treatment of rheumatoid arthritis, was synthesised and examined by NMR spectroscopy and X-ray crystallography. The derivative, which contains a trisimidazole phosphine, was designed to complex hard metals in addition to binding to the gold(I) centre.