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Process of economy transformation has had various impacts on individual regions of Slovakia. Developed regions with diversified branch structure were able to adapt with no serious problems, traditionally fossil and stagnant regions were not able to react to transformation process running and their stagnancy was getting deeper. Accordingly the number of regions with acute problems in economic and social development was extended. Different position, great contrasts in regions efficiency and level became a starting point that did not give a chance to solve their problems in medium horizont. It creates hard and very difficult emplacement of troubleshooting (fossil and stagnant) regions in their effort to achieve regional cohesion.