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Drug‐resistance is a serious problem for treatment of the HIV/AIDS pandemic. Potent clinical inhibitors of HIV‐1 protease show several orders of magnitude worse inhibition of highly drug‐resistant variants. Hence, the structure and enzyme activities were analyzed for HIV protease mutant HIV‐1 protease (EC 3.4.23.16) (PR) with 22 mutations (PRS5B) from a clinical isolate that was selected by machine...
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