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This paper describes a comparative study of two feedback control methods for a microfluidic electroporation (EP) system. The regulation of the transmembrane voltage (Vm) and nano-electropore radius (r) of HeLa cells on a micro EP chip was achieved using a linear Proportional-Integral-Derivative (PID) Controller and also Model Predictive Controller (MPC) based on the critical electric field for single-cell...
Microfiltration is an important microfluidic technique suitable for enrichment and isolation of cells. However, cell lysing could occur due to hydrodynamic damage that may be detrimental for medical diagnostics. Therefore, we conducted a systematic study of hydrodynamic cell lysing in a high-throughput Circular Multi-Channel Microfiltration (CMCM) device integrated with a polycarbonate membrane. HeLa...
A scalable polymer backplane for dense integration of photonics with lab-on-a-chip systems is presented. A high-throughput cell culture chip employing waveguides for monitoring and control of culture conditions is used to illustrate integration options.
As a part of effort to develop an artificial hair cell (AHC) sensor, we designed and fabricated a high-aspect-ratio/single cilium structure and a mechanoreceptor since they are the most important components for AHC sensor. The high-aspect-ratio single/cilium structure was successfully replicated by means of a hot embossing process with a help of a double-sided mold system. Especially for the high-aspect-ratio...
The failure mechanism of a monolithic MEMS twin-bubble micro-injector failed to eject ink smoothly has been investigated. A model that analyzes the thermal expansion mismatch among the nozzle plate, the silicon substrate, and the PPO housing is proposed to explain the failure mechanism of the MEMS micro-injector printing head. In the proposed model, the thickness of nozzle plate and the width of manifold...
This paper and presentation, for the first time, demonstrates a fully functional, packaged active microscaffold system with fluid perfusion and electrical stimulation/recording functionalities for 3-D neuronal culture studies. The fluid perfusion capabilities of the active microscaffold serve as an artificial circulatory system to enable 3-D growth and proliferation of re-aggregate neuronal cultures...
A platform is developed which utilizes polymer materials used for the chips to create waveguide based optical components. With the fabrication method demonstrated, waveguides, power splitters, combiners and bends can be introduced and integrated cheaply into existing biochips
Sensing biomolecules at minute quantities demands laborious and skill-laden laboratory protocols for sample preparation and amplification in order to improve signal-to-noise ratio. Nucleic-acid-based detection of viral particles in whole blood requires separation of viral particles from blood cells followed by extraction, amplification, and detection of viral nucleic acids. Here, three microfluidic...
Benzocyclobutene (BCB) based intracortical neural implants for basic neuroscience research in animal models was fabricated, in which microfluidic channel was embedded to deliver chemical reagents. BCB presents several attractive features for chronic applications: flexibility, biocompatibility, desirable chemical and electrical properties, and can be easily manufactured using existing batch microfabrication...
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