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Cytosolic nucleotidase II (cN‐II) from Legionella pneumophila (Lp) catalyzes the hydrolysis of GMP and dGMP displaying sigmoidal curves, whereas catalysis of IMP hydrolysis displayed a biphasic curve in the initial rate versus substrate concentration plots. Allosteric modulators of mammalian cN‐II did not activate LpcN‐II although GTP, GDP and the substrate GMP were specific activators. Crystal structures...
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