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This study was designed to determine if subchronic dosing of topical Tretinoin to the face of human subjects could alter endogenous plasma levels of tretinoin and isotretinoin.Eighteen healthy subjects (male and female) applied one of two 0.025% Tretinoin gels to their face for 28 consecutive days. On days 0, 7, 14, and 28 blood samples were collected at 0, 2, 4, 8, 10, 12, and 24 hr. Plasma was...
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