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A phenomenological mathematical model for predicting FFA-glucose-insulin dynamics during rest and exercise was developed. The dynamical effects of insulin on glucose and FFA were divided into three parts: (i) insulin-mediated glucose uptake by tissues, (ii) insulin-mediated suppression of endogenous glucose production, and (iii) anti-lipolytic effects of insulin. Labeled and unlabeled intravenous...
In the simplest model of protein production, a gene gives rise to a single protein; DNA is transcribed to form pre-mRNA, which is converted to mRNA by splicing or removing introns. The result is a chain of exons that is translated to form a protein. Alternative splicing of exons may result in the formation of multiple proteins from the same gene sequence. However, not all of these proteins may be...
We present a novel method to detect differentially expressed proteins in simulated two-dimensional electrophoresis (2DE) gels using spatial independent component analysis (ICA). We use an analysis-of-variance (ANOVA) approach as a benchmark for comparison and show that it yields improved detection power compared to currently used t-test based methods for 2DE gel analysis. However, ICA proves to be...
A mixed meal model was developed to capture the gut absorption of glucose, protein, and free fatty acid (FFA) from a mixed meal into the circulatory system. The output of the meal model served as a disturbance to the extended minimal model [3], which successfully captured plasma FFA, glucose and insulin concentration dynamics and interactions. A model predictive controller (MPC) was synthesized to...
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