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With the increase of data from genome sequencing projects comes the need for reliable and efficient methods for the analysis and classification of protein motifs and domains. Experimental methods currently used to determine protein structure are accurate, yet expensive both in terms of time and equipment. Therefore, various computational approaches to solving the problem have been attempted, although...
In the simplest model of protein production, a gene gives rise to a single protein; DNA is transcribed to form pre-mRNA, which is converted to mRNA by splicing or removing introns. The result is a chain of exons that is translated to form a protein. Alternative splicing of exons may result in the formation of multiple proteins from the same gene sequence. However, not all of these proteins may be...
Protein domains typically correspond to major functional sites of a protein. Therefore, determining similarity between domains can aid in the comparison of protein functions, and can provide a basis for grouping domains based on function. One strategy for comparing domain similarity and domain-protein similarity is to use similarity measurements of annotation terms from the Gene Ontology (GO). In...
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