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Neutral sphingomyelinase 1 (NSMase1) mediates caspase‐3 activation and apoptosis. However, the role of NSMase1, especially exosome‐borne NSMase1 in hepatocellular carcinoma (HCC), remains unclear. We report that NSMase1, which converts sphingomyelin (SM) to ceramide, was significantly downregulated in HCC tissues. Low NSMase1 expression predicted poor long‐term survival of HCC patients. NSMase1 downregulation...
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