Search results for: Koichi Tan-No

Items from 1 to 20 out of 82 results

article

Effect of Enterococcus faecalis 2001 on colitis and depressive-like behavior in dextran sulfate sodium-treated mice: involvement of the brain–gut axis

Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Takayo Odaira, more

Journal of Neuroinflammation > 2019 > 16 > 1 > 1-16

Background Patients with inflammatory bowel disease (IBD), including those with ulcerative colitis and Crohn’s disease, have higher rates of psychiatric disorders, such as depression and anxiety; however, the mechanism of psychiatric disorder development remains unclear. Mice with IBD induced by dextran sulfate sodium (DSS) in drinking water exhibit depressive-like behavior. The presence of Lactobacillus...

article

Anti‐hypersensitive effect of angiotensin (1‐7) on streptozotocin‐induced diabetic neuropathic pain in mice

Yoshiki Ogata, Wataru Nemoto, Ryota Yamagata, Osamu Nakagawasai, more

European Journal of Pain > 23 > 4 > 739 - 749

Background We have recently reported that the spinal angiotensin (Ang) converting enzyme (ACE)/Ang II/AT1 receptor axis and downstream p38 MAPK phosphorylation are activated in streptozotocin (STZ)‐induced diabetic mice and lead to tactile hypersensitivity. Moreover, our previous results suggested that the intrathecal (i.t.) administration of Ang (1‐7), an N‐terminal fragment of Ang II, may attenuate...

article

Etidronate attenuates tactile allodynia by spinal ATP release inhibition in mice with partial sciatic nerve ligation

Ryota Yamagata, Wataru Nemoto, Osamu Nakagawasai, Wan-Yi Hung, more

Naunyn-Schmiedeberg's Archives of Pharmacology > 2019 > 392 > 3 > 349-357

Etidronate is widely used as a therapeutic agent for osteoporosis. We have recently shown that intrathecal administration of etidronate into mice produces an analgesic effect against the capsaicin-induced nociceptive behavior. However, the effect of etidronate on neuropathic pain at the spinal level remains unknown. Therefore, we examined whether etidronate attenuates pain after partial sciatic nerve...

article

Memantine ameliorates depressive-like behaviors by regulating hippocampal cell proliferation and neuroprotection in olfactory bulbectomized mice

Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Shogo Kadota, more

Neuropharmacology > 2018 > 137 > C > 141-155

Our previous study suggested that the non-competitive N-methyl-d-aspartate receptor antagonist memantine (MEM) inhibits dopamine (DA) reuptake and turnover by inhibiting brain monoamine oxidase. Clinical studies have reported that MEM may improve depressive symptoms; however, specific mechanisms underlying this effect are unclear. We performed emotional behavior, tail suspension, and forced swimming...

article

Neutrophils Provide a Favorable IL-1-Mediated Immunometabolic Niche that Primes GLUT4 Translocation and Performance in Skeletal Muscles

Masahiro Tsuchiya, Shigenori Sekiai, Hiroyasu Hatakeyama, Masashi Koide, more

Cell Reports > 2018 > 23 > 8 > 2354-2364

Metabolic immunomodulation involving IL-1 has been investigated for unfavorable metabolic effects, including obesity, but a potentially favorable role for IL-1 remains unclear. Here, we find mechanistic interactions between working skeletal muscles and locally recruited neutrophils expressing IL-1β, which supports muscle performance through priming exercise-dependent GLUT4 translocation. Thus, during...

article

Involvement of peripheral alpha2A adrenoceptor in the acceleration of gastrointestinal transit and abdominal visceral pain induced by intermittent deprivation of REM sleep

Fukie Yaoita, Masamichi Muto, Hiroki Murakami, Shiori Endo, more

Physiology & Behavior > 2018 > 186 > C > 52-61

Many studies have associated sleep alterations with the severity of irritable bowel syndrome (IBS) symptoms, but the direct pathophysiological relationship has not been clarified. In addition, alterations in noradrenergic signaling have been implicated in the pathophysiology of IBS, and alpha2-adrenoceptors are potential treatment targets. We have previously shown that acceleration of gastrointestinal...

article

Inhibitory effect of angiotensin (1-7) on angiotensin III-induced nociceptive behaviour in mice

Wataru Nemoto, Ryota Yamagata, Yoshiki Ogata, Osamu Nakagawasai, more

Neuropeptides > 2017 > 65 > C > 71-76

We have previously demonstrated that the intrathecal (i.t.) administration of angiotensin (Ang) II into mice produces a nociceptive behaviour consisting of scratching, biting and licking accompanied by the phosphorylation of p38 MAPK in the spinal cord, which was mediated through AT1 receptors. Both the p38 MAPK phosphorylation and subsequent nociceptive behaviour were attenuated by the i.t. co-administration...

article

Time-dependent role of prefrontal cortex and hippocampus on cognitive improvement by aripiprazole in olfactory bulbectomized mice

Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Takayo Odaira, more

European Neuropsychopharmacology > 2017 > 27 > 10 > 1000-1010

Dopamine (DA) modulates cognitive functions in the prefrontal cortex (PFC) and hippocampus. Olfactory bulbectomy (OBX) in mice induces cognitive dysfunctions. Recently, we reported that aripiprazole (ARI) normalizes the behavioral hyper-responsivity to DA agonists in OBX mice. However, it remains unclear whether ARI affects OBX-induced cognitive dysfunctions. To address this question we evaluated...

article

Effects of methylphenidate on the impairment of spontaneous alternation behavior in mice intermittently deprived of REM sleep

Fukie Niijima-Yaoita, Yuka Nagasawa, Masahiro Tsuchiya, Yuichiro Arai, more

Neurochemistry International > 2016 > 100 > C > 128-137

Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. We have previously shown that abnormal behaviors elicited by intermittent rapid eye movement (REM) sleep deprivation stress may fulfill the profile of a model of ADHD. It is well known that the impairment of spontaneous alternation behavior (SAB) in the Y-maze...

article

Chondroitin sulfate attenuates formalin-induced persistent tactile allodynia

Wataru Nemoto, Kotaro Yamada, Yoshiki Ogata, Osamu Nakagawasai, more

Journal of Pharmacological Sciences > 2016 > 131 > 4 > 275-278

We examined the effect of chondroitin sulfate (CS), a compound used in the treatment of osteoarthritis and joint pain, on the formalin-induced tactile allodynia in mice. A repeated oral administration of CS (300 mg/kg, b.i.d.) significantly ameliorated the formalin-induced tactile allodynia from day 10 after formalin injection. On day 14, the phosphorylation of spinal p38 MAPK and subsequent increase...

article

BE360, a new selective estrogen receptor modulator, produces antidepressant and antidementia effects through the enhancement of hippocampal cell proliferation in olfactory bulbectomized mice

Osamu Nakagawasai, Wataru Nemoto, Hiroshi Onogi, Takahiro Moriya, more

Behavioural Brain Research > 2016 > 297 > C > 315-322

We have reported that the carborane compound BE360 is a novel selective estrogen receptor modulator and new therapy option for osteoporosis. The aim of this study was to explore the effects and underlying mechanisms of BE360 on depressive-like behavior and memory impairment in the olfactory bulbectomized (OBX) mice, an experimental animal model of depression and dementia. BE360 was administered subcutaneously...

article

Alterations in behavioral responses to dopamine agonists in olfactory bulbectomized mice: relationship to changes in the striatal dopaminergic system

Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Takeharu Nakajima, more

Psychopharmacology > 2016 > 233 > 7 > 1311-1322

Background Olfactory bulbectomy (OBX) in rodents is considered a putative animal model of depression. It has been reported that some abnormal behaviors observed in this animal model of depression involve dopaminergic neurons of the mesolimbic pathway. Therefore, we examined changes in the dopaminergic system in the caudate putamen (CPu), nucleus accumbens core (NAcC), and shell (NAcSh) of OBX mice...

article

Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice

Wataru Nemoto, Yoshiki Ogata, Osamu Nakagawasai, Fukie Yaoita, more

Neuropharmacology > 2015 > 99 > C > 221-231

We have previously demonstrated the possibility that angiotensin (Ang) II and its N-terminal metabolite Ang (1–7) act as neurotransmitters and/or neuromodulators in the spinal transmission of nociceptive information. Ang III, which is a C-terminal metabolite of Ang II, can also act on AT1 receptors, but its role in spinal nociceptive transmission remains unclear. Therefore, we examined the role of...

article

Liver hydrolysate attenuates the sickness behavior induced by concanavalin A in mice

Osamu Nakagawasai, Kotaro Yamada, Wataru Nemoto, Shin Sato, more

Journal of Pharmacological Sciences > 2015 > 127 > 4 > 489-492

Liver hydrolysate (LH) is used as a pharmaceutical agent in Japan, to enhance liver function. However, the effects of LH on sickness behavior are unknown. This study investigated the effect of LH on sickness behaviors, such as concanavalin A (ConA)-induced reduction of locomotor activity. ConA treatment significantly decreased locomotor activity. The striatal tyrosine hydroxylase (TH) levels were...

article

The intrathecal administration of losartan, an AT1 receptor antagonist, produces an antinociceptive effect through the inhibiton of p38 MAPK phosphorylation in the mouse formalin test

Wataru Nemoto, Yoshiki Ogata, Osamu Nakagawasai, Fukie Yaoita, more

Neuroscience Letters > 2015 > 585 > Complete > 17-22

We have recently reported that an intrathecal (i.t.) administration of angiotensin II (Ang II) into mice induces a nociceptive behavior accompanied by the activation of p38 MAPK signaling via AT ₁ receptors (Nemoto et al., 2013, Mol. Pain 9, 38). These results suggested that Ang II participates in the facilitation of nociceptive transmission in the spinal cord. In the present study, we used...

article

Long-term feeding on powdered food causes hyperglycemia and signs of systemic illness in mice

Masahiro Tsuchiya, Fukie Niijima-Yaoita, Hiroyuki Yoneda, Ko Chiba, more

Life Sciences > 2014 > 103 > 1 > 8-14

Dietary habits are crucial factors affecting metabolic homeostasis. However, few animal experiments have addressed the effects of long-term feeding with soft food on parameters reflecting systemic health.Using mice, we compared the effects of short (3days) and long (17weeks from weaning) feeding periods between powdered food and normal pellet food on the levels of blood glucose, serum levels of insulin,...

article

Influence of a long-term powdered diet on the social interaction test and dopaminergic systems in mice

Fukie Niijima-Yaoita, Masahiro Tsuchiya, Hiroko Saito, Yuka Nagasawa, more

Neurochemistry International > 2013 > 63 > 4 > 309-315

It is well known that the characteristics of mastication are important for the maintenance of our physical well-being. In this study, to assess the importance of the effects of food hardness during mastication, we investigated whether a long-term powdered diet might cause changes in emotional behavior tests, including spontaneous locomotor activity and social interaction (SI) tests, and the dopaminergic...

article

Phenylmethanesulfonyl fluoride, a serine protease inhibitor, suppresses naloxone-precipitated withdrawal jumping in morphine-dependent mice

Wataru Nemoto, Tasuku Sato, Osamu Nakagawasai, Fukie Yaoita, more

Neuropeptides > 2013 > 47 > 3 > 187-191

We have previously shown that intracerebroventricular (i.c.v.) administration of cysteine protease inhibitors suppresses naloxone-precipitated withdrawal jumping in morphine-dependent mice, presumably through the inhibition of dynorphin degradation (see (Tan-No, K., Sato, T., Shimoda, M., Nakagawasai, O., Niijima, F., Kawamura, S., Furuta, S., Sato, T., Satoh, S., Silberring, J., Terenius, L., Tadano,...

article

Interleukin-6 modulates oxidative stress produced during the development of cisplatin nephrotoxicity

Satoru Mitazaki, Midori Hashimoto, Yui Matsuhashi, Shigeyoshi Honma, more

Life Sciences > 2013 > 92 > 12 > 694-700

We reported that interleukin-6 (IL-6) plays a protective role in the development of cisplatin-induced acute renal failure (ARF) through upregulation of anti-oxidative stress factors. In this study, we examined the effects of dimethylthiourea (DMTU), a hydroxyl radical scavenger, on the development of cisplatin-induced ARF in wild-type (WT) and IL-6 ^−/− mice to determine how IL-6 contributes...

article

Chronic fluvoxamine treatment changes 5-HT2A/2C receptor-mediated behavior in olfactory bulbectomized mice

Akira Oba, Osamu Nakagawasai, Hiroshi Onogi, Wataru Nemoto, more

Life Sciences > 2013 > 92 > 2 > 119-124

Olfactory bulbectomy (OBX) in rodents represents a valuable experimental model of depression. This study was designed to shed further light on the impact of putative serotonergic neuronal degeneration in OBX mice and to assess the effect of a widely used antidepressant on serotonergic related behavioral changes induced by OBX.Adult male ddY mice were subject to bilateral OBX or sham surgery. The serotonin...

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Search results for: Koichi Tan-No

Effect of Enterococcus faecalis 2001 on colitis and depressive-like behavior in dextran sulfate sodium-treated mice: involvement of the brain–gut axis

Anti‐hypersensitive effect of angiotensin (1‐7) on streptozotocin‐induced diabetic neuropathic pain in mice

Etidronate attenuates tactile allodynia by spinal ATP release inhibition in mice with partial sciatic nerve ligation

Memantine ameliorates depressive-like behaviors by regulating hippocampal cell proliferation and neuroprotection in olfactory bulbectomized mice

Neutrophils Provide a Favorable IL-1-Mediated Immunometabolic Niche that Primes GLUT4 Translocation and Performance in Skeletal Muscles

Involvement of peripheral alpha2A adrenoceptor in the acceleration of gastrointestinal transit and abdominal visceral pain induced by intermittent deprivation of REM sleep

Inhibitory effect of angiotensin (1-7) on angiotensin III-induced nociceptive behaviour in mice

Time-dependent role of prefrontal cortex and hippocampus on cognitive improvement by aripiprazole in olfactory bulbectomized mice

Effects of methylphenidate on the impairment of spontaneous alternation behavior in mice intermittently deprived of REM sleep

Chondroitin sulfate attenuates formalin-induced persistent tactile allodynia

BE360, a new selective estrogen receptor modulator, produces antidepressant and antidementia effects through the enhancement of hippocampal cell proliferation in olfactory bulbectomized mice

Alterations in behavioral responses to dopamine agonists in olfactory bulbectomized mice: relationship to changes in the striatal dopaminergic system

Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice

Liver hydrolysate attenuates the sickness behavior induced by concanavalin A in mice

The intrathecal administration of losartan, an AT1 receptor antagonist, produces an antinociceptive effect through the inhibiton of p38 MAPK phosphorylation in the mouse formalin test

Long-term feeding on powdered food causes hyperglycemia and signs of systemic illness in mice

Influence of a long-term powdered diet on the social interaction test and dopaminergic systems in mice

Phenylmethanesulfonyl fluoride, a serine protease inhibitor, suppresses naloxone-precipitated withdrawal jumping in morphine-dependent mice

Interleukin-6 modulates oxidative stress produced during the development of cisplatin nephrotoxicity

Chronic fluvoxamine treatment changes 5-HT2A/2C receptor-mediated behavior in olfactory bulbectomized mice

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