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Alpha-fetoprotein (AFP) is an oncofetal antigen during hepatocellular carcinoma (HCC) development which could lead to weak reproducible antitumor immunity, and may act as a target for cancer therapy. Therefore, it is imperative to enhance its immunogenicity and develop therapeutic vaccines to eliminate AFP-expressing tumors. In this study, by way of glutaraldehyde cross-linking, we constructed a potential...
Considerable arguments remain regarding the diverse biological activities of polyunsaturated fatty acids (PUFA). One of the most interesting but controversial dietary approaches focused on the diverse function of dihomo-dietary γ-linolenic acid (DGLA) in anti-inflammation and anti-proliferation diseases, especially for cancers. This strategy is based on the ability of DGLA to interfere in cellular...
Arsenic exposure from drinking water was considered to be a risk factor for skin lesions. In our research, the total arsenic in water and urine samples were analyzed by ICP-MS and AFS, respectively, Arsenic concentration in drinking water was 4.04–720μg/L, and there were 63.49% (80/126) samples above 50μg/L. Urinary total arsenic concentration was 6.51–775.73μg/gCr. Spearman rank correlation was used...
Purpose: To explore the anti-tumor effect of the Shenfouweikang in treatment of gastric cancer. Methods: Nude mice grafted with a human gastric adenocarcinoma cell line BGC-823 was used as the experimental model. The mice were divided into three groups, one control and the two drug administration experimental groups. Animals in the two experimental groups received either Shefouweikang or Dele granule...
Background: CD44v6 is a splice variant of CD44 (CD44v) could probably promote cancer cells to adhere to vascular endothelium and base membranes and enhancing the invasion and metastasis of colonic carcinomas. Heat shock protein 72 (HSP72) as a molecular chaperone has been confirmed to overexpress in epithelial carcinoma cells. There may be a possible correlation between the expression of HSP72 and...
Background: CD44v6 is a splice variant of CD44 (CD44v) could probably promote cancer cells to adhere to vascular endothelium and base membranes and enhancing the invasion and metastasis of colonic carcinomas. Heat shock protein 72 (HSP72) as a molecular chaperone has been confirmed to overexpress in epithelial carcinoma cells. There may be a possible correlation between the expression of HSP72 and...
To construct a recombinant vaccine alpha-fetoprotein (AFP)-heat shock protein (HSP70) complex, and study its ability to induce specific cytotoxic T lymphocyte (CTL) response and its protective effect against AFP-producing tumor. A recombinant vaccine was constructed by conjugating mouse heat shock protein 70. By way of intracutaneous injection, mice were primed and boosted with recombinant vaccine...
In this study, we developed GNPs with various types of chemical surface features and evaluated how these features led nanoparticles to selectively bind to different target cell sites. Results showed that selective binding was successful in producing high concentrations in target locations. We also explored the potential application of these GNPs to enhance the cancer cell cytotoxicity induced by radiotherapy.
We are facing tremendous opportunities and challenges in combining emerging nanotechnology with genomic signal processing techniques in developing faster, smaller, yet more accurate and sensitive biomedical devices in cancer genomics and proteomics. The goal is to better understand the cancer mechanisms at the cellular and even subcellular levels. Nanotechnology has been applied to study the dynamic...
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