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Membrane‐type 1 matrix metalloproteinase (MT1‐MMP) is a proteinase involved in the remodelling of extracellular matrix and the cleavage of a number of substrates. MT1‐MMP is synthesized as a zymogen that requires intracellular post‐translational cleavage to gain biological activity. Furin, a member of the pro‐protein convertase family, has been implicated in the proteolytic removal of the MT1‐MMP...
The close correlation observed between matrix metalloproteinase 2 (MMP-2) activation and metastatic progression in various tumors suggests that MMP-2 is a `master switch' triggering tumor spread. Recently, membrane type 1 MMP (MT1-MMP) was identified as a potential physiological activator of MMP-2. Like all other MMPs, MT1-MMP possesses a pro-domain which must be removed for the enzyme to acquire...
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