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Matrix metalloproteinases (MMPs) are a group of structurally related proteolytic enzymes containing a zinc ion in the active site. They are secreted from cells or bound to the plasma membrane and hydrolyze extracellular matrix (ECM) and cell surface‐bound molecules. They therefore play key roles in morphogenesis, wound healing, tissue repair and remodeling in diseases such as cancer and arthritis...
Membrane‐type 1 matrix metalloproteinase (MT1‐MMP) is a proteinase involved in the remodelling of extracellular matrix and the cleavage of a number of substrates. MT1‐MMP is synthesized as a zymogen that requires intracellular post‐translational cleavage to gain biological activity. Furin, a member of the pro‐protein convertase family, has been implicated in the proteolytic removal of the MT1‐MMP...
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