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CC and CXC chemokines are distinct chemokine subfamilies. CC chemokines usually do not bind CXC‐chemokine receptors and vice versa. CCR5 and CXCR4 receptors are activated by CCL5 and CXCL12 chemokines, respectively, and are also used as HIV‐1 coreceptors. CCL5 contains one conserved binding site for a sulfated tyrosine residue, whereas CXCL12 is unique in having two additional sites for sulfated/nonsulfated...
The N‐terminal segment of the chemokine receptor Human CC chemokine receptor 5 (CCR5), Nt‐CCR5, contains four tyrosine residues, Y3, Y10, Y14, and Y15. Sulfation of at least two of these tyrosine residues was found to be essential for high‐affinity binding of CCR5 to its chemokine ligands. Here, we show that among the monosulfated Nt‐CCR5(8‐20) peptide surrogates (sNt‐CCR5) those sulfated at Y15 and...
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