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Human guanylate‐binding protein 1 (hGBP‐1) shows a dimer‐induced acceleration of the GTPase activity yielding GDP as well as GMP. While the head‐to‐head dimerization of the large GTPase (LG) domain is well understood, the role of the rest of the protein, particularly of the GTPase effector domain (GED), in dimerization and GTP hydrolysis is still obscure. In this study, with truncations and point...
Human guanylate‐binding protein 1 (hGBP1) belongs to the superfamily of large, dynamin‐related GTPases. The expression of hGBP1 is induced by stimulation with interferons (mainly interferon‐γ), and it plays a role in different cellular responses to inflammatory cytokines, e.g. pathogen defence, control of proliferation, and angiogenesis. Although other members of the dynamin superfamily show a diversity...
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