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The Laboratory of Molecular Imaging and Nanomedicine (LOMIN) was initiated in 2009 at the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering and has been led by Xiaoyuan (Shawn) Chen. Currently, LOMIN has grown to over 25 members who work together in diverse fields to develop theranostic molecular imaging tools and drug delivery systems. LOMIN is an interdisciplinary...
Summary form only given. Ferritin is a family of proteins found in different forms in most living organisms. Each ferritin is made up of 24 subunits, which self-assemble to form a cage-like nanostructure, with external and internal diameters of 12 and 8 nm, respectively. This unique architecture provides two interfaces-one outside and one inside-for possible functional loading. These interesting features...
Recently portable Raman probes have emerged into markets with a variety of applications including carbon nanotube (CNTs) characterization. Aqueous dispersed carbon nanotubes (CNTs) have shown a lot of promise towards biomedical application like drug / gene delivery vectors, photo-thermal therapy, and photoacoustic imaging. In this study we report the simultaneous detection and irradiation of carbon...
History has witnessed an enormous progress of developing nanocrystals into “smart” probes for either imaging or therapeutic applications. Such progress is in large part powered by our ability to manipulate the surface of nanoparticles, marked by the establishment of surface engineering techniques that permit facile docking of functional motifs onto particles. However, these techniques have been increasingly...
Most new drug candidates generated during in vitro screenings turn out to be invalid after time-consuming and costly testing in animal models. Therefore, development of noninvasive, real-time, sensitive, and cost-effective tools with higher throughput for monitoring and early detection of drug efficacy in vivo is urgently needed. Of such techniques, optical molecular imaging provides many advantages...
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